These activities were segregated by the tag-SNP rs 1495741 and each of the seven SNPs described above. Materials & methods Sulfamethazine N-acetyltransferase catalytic activities were measured in cryopreserved human hepatocytes from a convenience sample of individuals in the USA with an ethnic frequency similar to the 2010 US population census. A tag-SNP ( rs 1495741) recently identified in a genome-wide association study has also been proposed as a biomarker for the NAT2 phenotype. The majority of studies investigate the NAT2 genotype assay for three SNPs: 481C>T, 590G>A and 857G>A. Over 65 NAT2 variants possessing one or more SNPs in the 870-bp NAT2 coding region have been reported. Accuracy of various human NAT2 SNP genotyping panels to infer rapid, intermediate and slow acetylator phenotypesĪim Humans exhibit genetic polymorphism in NAT2 resulting in rapid, intermediate and slow acetylator phenotypes.
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